A KATP opener inhibited myocardial reperfusion action potential shortening and arrhythmias
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چکیده
channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias.
منابع مشابه
Liver ischemia preconditions the heart against ischemia-reperfusion arrhythmias
Objective(s):This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. Materials and Methods: Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induce...
متن کاملThe effects of ATP-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in rats
Objective(s): Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (KATP) channel blocker (gl...
متن کاملCardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.
BACKGROUND We recently demonstrated that the sarcolemmal ATP-sensitive potassium (sarcK(ATP)) channel plays a key role in cardioprotection against ischemia/reperfusion injuries in Kir6.2-knockout (KO) mice. In the present study, we evaluated the effects of diazoxide, a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel opener, on ischemia-induced myocardial stunning in sarcK(ATP) channe...
متن کاملDifferential Effects of Sarcolemmal and Mitochondrial KATP Channels Activated by 17 -Estradiol on Reperfusion Arrhythmias and Infarct Sizes in Canine Hearts
We have demonstrated the effects of estrogen on modulation of ATP-sensitive K channels; however, the subcellular location of these channels is unknown. The purpose of the present study was to investigate the role of the sarcolemmal and mitochondrial ATP-sensitive K channels in a canine model of myocardial infarction after stimulation with 17 -estradiol. Anesthetized dogs were subjected to 60 mi...
متن کاملLiver ischemia preconditions the heart against ischemia-reperfusion arrhythmias
OBJECTIVES This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. MATERIALS AND METHODS Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induced...
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تاریخ انتشار 2009